# Xiao Chen Source: https://hello.cv/xiaochen ## About Xiao Chen is a Professor of the Laboratory of Marine Protozoan Biodiversity & Evolution, affiliated with Marine College at Shandong University. His group aims to delineate mechanisms underlying chromatin regulation and genome evolution using eukaryotic cell models. Dr. Chen has been focusing on the epigenetic regulation mechanism of cellular homeostasis maintenance using eukaryotic models including ciliate. The findings are highlighted as follows: 1) Clarified the gene transcription pattern and omics basis for maintaining cellular homeostasis under environmental stress, laying the foundation for further exploration of its epigenetic regulation mechanism; 2) Elucidated the molecular mechanisms by which epigenetic factors alter gene transcription levels and regulate cellular homeostasis, expanding our understanding of the involvement of epigenetic factors in regulating cellular homeostasis; 3) Revealed the pathogenic mechanism of cellular homeostasis imbalance caused by chromatin dysregulation and confirmed the potential diagnostic and therapeutic value of epigenetic regulation of cellular homeostasis. These findings have led to more than 40 publications in high-impact journals including Nature Communications, PNAS, and Molecular Cell. Dr. Chen's work was highly recognized by distinguished experts in chromatin fields as "a crucial discovery that will provide key information for current and future drug development" and "an important study that further illuminates on the role oncohistones have in gene transcription regulation". Currently, the research on the dysregulation of gene transcription by chromatin states has been hampered by a lack of rationalized systems to dig deep into the underlying mechanism. Dr. Chen hereby aims to further explore the roles of histone modifications in regulating gene transcription and maintaining cell physiological and structural stability, in response to the key question of how unicellular eukaryotes maintain cellular homeostasis. ## Education ### Ocean University of China | PhD ## Publications ### Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy Science Advances journal-article ### Genes and proteins expressed at different life cycle stages in the model protist Euplotes vannus revealed by both transcriptomic and proteomic approaches Science China Life Sciences journal-article ### Rosiglitazone and trametinib exhibit potent anti-tumor activity in a mouse model of muscle invasive bladder cancer Nature Communications journal-article ### Genomic insights into the cellular specialization of predation in raptorial protists BMC Biology journal-article ### Single-cell transcriptomic analysis reveals genome evolution in predatory litostomatean ciliates European Journal of Protistology journal-article ### Decryption of the survival “black box”: gene family expansion promotes the encystment in ciliated protists BMC Genomics journal-article ### Metabolic reprogramming by histone deacetylase inhibition preferentially targets NRF2-activated tumors Cell Reports journal-article ### SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion Cell journal-article ### Recognition of histone methylation and DNA by the PWWP domain: Mechanism and function Chromatin Readers in Health and Disease book-chapter ### Invasion by exogenous RNA: cellular defense strategies and implications for RNA inference Marine Life Science & Technology journal-article ### New evidence of consistency between phylogeny and morphology for two taxa in ciliated protists, the subclasses Oligotrichia and Choreotrichia (Protista, Ciliophora) Molecular Phylogenetics and Evolution journal-article ### Editorial: Biomedical application of DNA modifications Frontiers in Genetics journal-article ### Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma Nature Communications journal-article ### Single-cell transcriptome reveals cell division-regulated hub genes in the unicellular eukaryote Paramecium European Journal of Protistology journal-article ### Comparative genome analysis of three euplotid protists provides insights into the evolution of nanochromosomes in unicellular eukaryotic organisms Marine Life Science & Technology journal-article ### Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration Cell journal-article ### Annotation and evaluation of base editing outcomes in multiple cell types using CRISPRbase. Nucleic acids research journal-article ### Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas. Molecular Cell journal-article ### Comparative Genome Analysis Reveals Cis-Regulatory Elements on Gene-Sized Chromosomes of Ciliated Protists Frontiers in Microbiology journal-article ### Comparative Genome Analysis Reveals Cis-Regulatory Elements on Gene-Sized Chromosomes of Ciliated Protists Frontiers in Microbiology journal-article ### Comparative Genome Analysis Reveals Cis-Regulatory Elements on Gene-Sized Chromosomes of Ciliated Protists. Frontiers in microbiology journal-article ### The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly PLOS Genetics journal-article ### CHAF1A/B mediate silencing of unintegrated HIV-1 DNAs early in infection Proceedings of the National Academy of Sciences journal-article ### Pparg signaling controls bladder cancer subtype and immune exclusion Nature Communications journal-article ### Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks Molecular Cell journal-article ### Growth Inhibition and Induction of Innate Immune Signaling of Chondrosarcomas with Epigenetic Inhibitors. Molecular cancer therapeutics journal-article ### Overview of the Diversity, Phylogeny and Biogeography of Strombidiid Oligotrich Ciliates (Protista, Ciliophora), With a Brief Revision and a Key to the Known Genera. Frontiers in microbiology journal-article ### Chromosome organization and gene expansion in the highly fragmented genome of the ciliate Strombidium stylifer Journal of Genetics and Genomics journal-article ### Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands. Nature genetics journal-article ### The interplay between DNA and histone methylation: molecular mechanisms and disease implications. EMBO Reports journal-article ### Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation Proc Natl Acad Sci U S A journal-article ### Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma. Cell Reports journal-article ### Functional interrogation of DNA damage response variants with base editing screens. Cell journal-article ### Single-Cell Genomic Sequencing of Three Peritrichs (Protista, Ciliophora) Reveals Less Biased Stop Codon Usage and More Prevalent Programmed Ribosomal Frameshifting Than in Other Ciliates Frontiers in Marine Science journal-article ### The INO80 Complex Regulates Epigenetic Inheritance of Heterochromatin Cell Reports journal-article ### Characterization of Simple Sequence Repeats (SSRs) in Ciliated Protists Inferred by Comparative Genomics Microorganisms journal-article ### Functional analysis of the methyltransferase SMYD in the single-cell model organism Tetrahymena thermophila Marine Life Science & Technology journal-article ### Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells Nature Communications journal-article ### Our recent progress in epigenetic research using the model ciliate, Tetrahymena thermophila Marine Life Science & Technology journal-article ### The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape Nature journal-article ### Further analyses on the evolutionary “key‐protist” Halteria (Protista, Ciliophora) based on transcriptomic data Zoologica Scripta journal-article ### Genome analyses of the new model protist Euplotes vannus focusing on genome rearrangement and resistance to environmental stressors Molecular Ecology Resources journal-article ### RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena Genes & Development journal-article ### Genome analysis of the unicellular eukaryote Euplotes vannus provides insights into mating type determination and tolerance to environmental stresses other ### GPSit: An automated method for evolutionary analysis of nonculturable ciliated microeukaryotes Molecular Ecology Resources journal-article ### N6-adenine DNA methylation is associated with the linker DNA of H2A.Z-containing well-positioned nucleosomes in Pol II-transcribed genes in Tetrahymena Nucleic Acids Research journal-article ### A comparative study of genome organization and epigenetic mechanisms in model ciliates, with an emphasis on Tetrahymena , Paramecium and Oxytricha European Journal of Protistology journal-article ### A germline-limited piggyBac transposase gene is required for precise excision in Tetrahymena genome rearrangement Nucleic Acids Research journal-article ### Enzymatic and chemical mapping of nucleosome distribution in purified micro- and macronuclei of the ciliated model organism, Tetrahymena thermophila Science China Life Sciences journal-article ### Enzymatic and chemical mapping of nucleosome distribution in purified micro- and macronuclei of the ciliated model organism, Tetrahymena thermophila. journal-article ### Dissecting relative contributions ofcis- andtrans-determinants to nucleosome distribution by comparingTetrahymenamacronuclear and micronuclear chromatin Nucleic Acids Research journal-article ### Phylogenomics of non-model ciliates based on transcriptomic analyses Protein & Cell journal-article ### Phylogenomics of non-model ciliates based on transcriptomic analyses. journal-article ### Molecular data suggests the ciliate Mesodinium (Protista: Ciliophora) might represent an undescribed taxon at class level Zoological Systematics journal-article ### New considerations on the phylogeny of cyrtophorian ciliates (Protozoa, Ciliophora): expanded sampling to understand their evolutionary relationships Zoologica Scripta journal-article ## Source Read this profile on Hello.cv: https://hello.cv/xiaochen Create your free profile at https://hello.cv